Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells.

Saved in:

Bibliographic Details
Title:	Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells.
Authors:	Plikus, Maksim V., Baker, Ruth E., Chih-Chiang Chen, Fare, Clyde, de la Cruz, Damon, Andl, Thomas, Maini, Philip K., Millar, Sarah E., Widelitz, Randall, Cheng-Ming Chuong
Source:	Science (pre-March 2025). 4/29/2011, Vol. 332 Issue 6029, p586-589. 4p.
Subjects:	Stem cell research, Hair cell regeneration, Self-organizing systems, Hair follicle physiology, Cell communication, Wnt proteins, Bone morphogenetic proteins
Abstract:	Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs. [ABSTRACT FROM AUTHOR]
	Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs. [ABSTRACT FROM AUTHOR]
ISSN:	00368075
DOI:	10.1126/science.1201647