Function, Targets, and Evolution of Caenorhabditis elegans piRNAs.

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Bibliographic Details
Title:	Function, Targets, and Evolution of Caenorhabditis elegans piRNAs.
Authors:	Bagijn, Marloes P., Goldstein, Leonard D., Sapetschnig, Alexandra, Weick, Eva-Maria, Bouasker, Samir, Lehrbach, Nicolas J., Simard, Martin J., Miska, Eric A.
Source:	Science (pre-March 2025). 8/3/2012, Vol. 337 Issue 6094, p574-578. 5p.
Subjects:	Piwi genes, Genetic transcription regulation, Genetic transformation, RNA interference, Small interfering RNA, Heredity, Caenorhabditis elegans genetics, Nematode genetics
Abstract:	This article discusses the study of Piwi-interacting RNAs' (piRNAs) ability to maintain germline integrity in Caenorhabditis elegans nematodes through the use of targeted transcription silencing. Topics include piRNAs' use of a localized secondary endogenous small interfering RNA (endo-siRNA) response to perform the silencing, the depletion of protein-coding genes at genomic locations of piRNA biogenesis, and the conclusions that nematode piRNA clusters are evolving to allow for the heritable ability to generate piRNAs as a defense against active mobile elements in RNA interference.
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	This article discusses the study of Piwi-interacting RNAs' (piRNAs) ability to maintain germline integrity in Caenorhabditis elegans nematodes through the use of targeted transcription silencing. Topics include piRNAs' use of a localized secondary endogenous small interfering RNA (endo-siRNA) response to perform the silencing, the depletion of protein-coding genes at genomic locations of piRNA biogenesis, and the conclusions that nematode piRNA clusters are evolving to allow for the heritable ability to generate piRNAs as a defense against active mobile elements in RNA interference.
ISSN:	00368075
DOI:	10.1126/science.1220952