Function, Targets, and Evolution of Caenorhabditis elegans piRNAs.
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| Title: | Function, Targets, and Evolution of Caenorhabditis elegans piRNAs. |
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| Authors: | Bagijn, Marloes P., Goldstein, Leonard D., Sapetschnig, Alexandra, Weick, Eva-Maria, Bouasker, Samir, Lehrbach, Nicolas J., Simard, Martin J., Miska, Eric A. |
| Source: | Science (pre-March 2025). 8/3/2012, Vol. 337 Issue 6094, p574-578. 5p. |
| Subjects: | Piwi genes, Genetic transcription regulation, Genetic transformation, RNA interference, Small interfering RNA, Heredity, Caenorhabditis elegans genetics, Nematode genetics |
| Abstract: | This article discusses the study of Piwi-interacting RNAs' (piRNAs) ability to maintain germline integrity in Caenorhabditis elegans nematodes through the use of targeted transcription silencing. Topics include piRNAs' use of a localized secondary endogenous small interfering RNA (endo-siRNA) response to perform the silencing, the depletion of protein-coding genes at genomic locations of piRNA biogenesis, and the conclusions that nematode piRNA clusters are evolving to allow for the heritable ability to generate piRNAs as a defense against active mobile elements in RNA interference. |
| Database: | Psychology and Behavioral Sciences Collection |
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