View in EDS HTML Full Text PDF Full Text

Contribution of serotonin uptake and degradation to myocardial interstitial serotonin levels during ischaemia-reperfusion in rabbits.

Saved in:
Bibliographic Details
Title: Contribution of serotonin uptake and degradation to myocardial interstitial serotonin levels during ischaemia-reperfusion in rabbits.
Authors: Sonobe, T., Akiyama, T., Du, C.‐K., Zhan, D.‐Y., Shirai, M.
Source: Acta Physiologica. Feb2013, Vol. 207 Issue 2, p260-268. 9p. 3 Diagrams, 1 Chart, 2 Graphs.
Subjects: Serotonin uptake inhibitors, Cardiomyopathies, Serotonin, Ischemia, Reperfusion, Laboratory rabbits, Monoamine oxidase
Abstract: Aim Although deleterious effects of serotonin (5- HT) have been demonstrated during myocardial ischaemia-reperfusion, little information is available on myocardial interstitial 5- HT kinetics. This study evaluated the contribution of 5- HT reuptake and degradation to myocardial interstitial 5- HT levels during ischaemia-reperfusion. Methods Using microdialysis technique in anaesthetized rabbits, we monitored myocardial interstitial 5- HT levels in the ischaemic region during ischaemia (30 min) followed by reperfusion (60 min) and investigated the effects of local infusion of fluoxetine, a 5- HT uptake inhibitor, and/or pargyline, a monoamine oxidase inhibitor. Results In vehicle control, dialysate 5-HT concentration increased gradually from 16 ± 3 at baseline to 85 ± 18 n m during 20-30 min of ischaemia. Dialysate 5-HT concentration further increased to 236 ± 47 n m at 0-10 min of reperfusion and then began to decline. Averaged 5-HT concentration was 61 ± 11 during ischaemia and 113 ± 13 n m during reperfusion. Fluoxetine elevated dialysate 5-HT level at baseline and at 10-30 min of reperfusion; it increased averaged dialysate 5-HT concentration by approx. 304% during reperfusion compared to control. Pargyline elevated averaged dialysate 5-HT concentration during ischaemia by approx. 243% and that during reperfusion by approx. 250% compared to control. The changes in dialysate 5-HT concentration by fluoxetine + pargyline were similar to those of fluoxetine alone. Conclusion The 5- HT reuptake function plays an important role in the clearance of myocardial interstitial 5- HT during reperfusion. When 5- HT reuptake function is intact, degradation of 5- HT by monoamine oxidase contributes to reduce myocardial interstitial 5- HT level throughout ischaemia-reperfusion. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 84652639
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Contribution of serotonin uptake and degradation to myocardial interstitial serotonin levels during ischaemia-reperfusion in rabbits.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Sonobe%2C+T%2E%22">Sonobe, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Akiyama%2C+T%2E%22">Akiyama, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Du%2C+C%2E‐K%2E%22">Du, C.‐K.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhan%2C+D%2E‐Y%2E%22">Zhan, D.‐Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Shirai%2C+M%2E%22">Shirai, M.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Feb2013, Vol. 207 Issue 2, p260-268. 9p. 3 Diagrams, 1 Chart, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Serotonin+uptake+inhibitors%22">Serotonin uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiomyopathies%22">Cardiomyopathies</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemia%22">Ischemia</searchLink><br /><searchLink fieldCode="DE" term="%22Reperfusion%22">Reperfusion</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rabbits%22">Laboratory rabbits</searchLink><br /><searchLink fieldCode="DE" term="%22Monoamine+oxidase%22">Monoamine oxidase</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim Although deleterious effects of serotonin (5- HT) have been demonstrated during myocardial ischaemia-reperfusion, little information is available on myocardial interstitial 5- HT kinetics. This study evaluated the contribution of 5- HT reuptake and degradation to myocardial interstitial 5- HT levels during ischaemia-reperfusion. Methods Using microdialysis technique in anaesthetized rabbits, we monitored myocardial interstitial 5- HT levels in the ischaemic region during ischaemia (30 min) followed by reperfusion (60 min) and investigated the effects of local infusion of fluoxetine, a 5- HT uptake inhibitor, and/or pargyline, a monoamine oxidase inhibitor. Results In vehicle control, dialysate 5-HT concentration increased gradually from 16 ± 3 at baseline to 85 ± 18 n m during 20-30 min of ischaemia. Dialysate 5-HT concentration further increased to 236 ± 47 n m at 0-10 min of reperfusion and then began to decline. Averaged 5-HT concentration was 61 ± 11 during ischaemia and 113 ± 13 n m during reperfusion. Fluoxetine elevated dialysate 5-HT level at baseline and at 10-30 min of reperfusion; it increased averaged dialysate 5-HT concentration by approx. 304% during reperfusion compared to control. Pargyline elevated averaged dialysate 5-HT concentration during ischaemia by approx. 243% and that during reperfusion by approx. 250% compared to control. The changes in dialysate 5-HT concentration by fluoxetine + pargyline were similar to those of fluoxetine alone. Conclusion The 5- HT reuptake function plays an important role in the clearance of myocardial interstitial 5- HT during reperfusion. When 5- HT reuptake function is intact, degradation of 5- HT by monoamine oxidase contributes to reduce myocardial interstitial 5- HT level throughout ischaemia-reperfusion. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=84652639
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/j.1748-1716.2012.02461.x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 260
    Subjects:
      – SubjectFull: Serotonin uptake inhibitors
        Type: general
      – SubjectFull: Cardiomyopathies
        Type: general
      – SubjectFull: Serotonin
        Type: general
      – SubjectFull: Ischemia
        Type: general
      – SubjectFull: Reperfusion
        Type: general
      – SubjectFull: Laboratory rabbits
        Type: general
      – SubjectFull: Monoamine oxidase
        Type: general
    Titles:
      – TitleFull: Contribution of serotonin uptake and degradation to myocardial interstitial serotonin levels during ischaemia-reperfusion in rabbits.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sonobe, T.
      – PersonEntity:
          Name:
            NameFull: Akiyama, T.
      – PersonEntity:
          Name:
            NameFull: Du, C.‐K.
      – PersonEntity:
          Name:
            NameFull: Zhan, D.‐Y.
      – PersonEntity:
          Name:
            NameFull: Shirai, M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2013
              Type: published
              Y: 2013
          Identifiers:
            – Type: issn-print
              Value: 17481708
          Numbering:
            – Type: volume
              Value: 207
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Acta Physiologica
              Type: main
ResultId 1