Bibliographic Details
| Title: |
The relationships among knowledge, self-efficacy, preparedness, decisional conflict, and decisions to participate in a cancer clinical trial. |
| Authors: |
Miller, S. M., Hudson, S. V., Egleston, B. L., Manne, S., Buzaglo, J. S., Devarajan, K., Fleisher, L., Millard, J., Solarino, N., Trinastic, J., Meropol, N. J. |
| Source: |
Psycho-Oncology. Mar2013, Vol. 22 Issue 3, p481-489. 9p. 2 Diagrams, 5 Charts. |
| Subjects: |
Clinical trials, Cancer patients, Self-efficacy, Decision making, Informed consent (Medical law) |
| Abstract: |
Background Cancer clinical trials (CCTs) are important tools in the development of improved cancer therapies; yet, participation is low. Key psychosocial barriers exist that appear to impact a patient's decision to participate. Little is known about the relationship among knowledge, self-efficacy, preparation, decisional conflict, and patient decisions to take part in CCTs. Objective The purpose of this study was to determine if preparation for consideration of a CCT as a treatment option mediates the relationship between knowledge, self-efficacy, and decisional conflict. We also explored whether lower levels of decisional conflict are associated with greater likelihood of CCT enrollment. Method In a pre-post test intervention study, cancer patients ( N = 105) were recruited before their initial consultation with a medical oncologist. A brief educational intervention was provided for all patients. Patient self-report survey responses assessed knowledge, self-efficacy, preparation for clinical trial participation, decisional conflict, and clinical trial participation. Results Preparation was found to mediate the relationship between self-efficacy and decisional conflict ( p = 0.003 for a test of the indirect mediational pathway for the decisional conflict total score). Preparation had a more limited role in mediating the effect of knowledge on decisional conflict. Further, preliminary evidence indicated that reduced decisional conflict was associated with increased clinical trial enrollment ( p = 0.049). Conclusions When patients feel greater CCT self-efficacy and have more knowledge, they feel more prepared to make a CCT decision. Reduced decisional conflict, in turn, is associated with the decision to enroll in a clinical trial. Our results suggest that preparation for decision-making should be a target of future interventions to improve participation in CCTs. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
