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Deuteron-induced nuclear reactions to produce 177Lu: Extension of cross-sections data up to 33 MeV and impact on purity.

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Title: Deuteron-induced nuclear reactions to produce 177Lu: Extension of cross-sections data up to 33 MeV and impact on purity.
Authors: López-Melero, E.1 (AUTHOR) melopez@ugr.es, Nigron, E.2 (AUTHOR), Haddad, F.2,3 (AUTHOR), Praena, J.1 (AUTHOR)
Source: Applied Radiation & Isotopes. Jan2026, Vol. 227, pN.PAG-N.PAG. 1p.
Subjects: Deuteron reactions, Radioisotopes, Metastable states, Isotope separation, Nuclear activation analysis, Gamma ray spectrometry, Nuclear medicine
Abstract: Activation cross-sections of lutetium and ytterbium radionuclides have been measured by deuteron-induced nuclear reaction on n a t Yb(d,x) at the GIP ARRONAX (Saint-Herblain, France) cyclotron facility with a beam energy up to 33 MeV using the stacked-foil activation technique combined with high resolution γ -ray spectrometry. The measured experimental values enable the extension of the cross-section to higher energies. As a primary objective, we have focused on the cumulative measurement of the direct and indirect production routes of the therapeutic radioisotope 177 g Lu, via 176Yb(d,n) 177 g , m Lu and 176Yb(d,p) 177Yb → 177 g Lu respectively. Post-irradiation gamma analysis, including a long gamma counting period, was performed to calculate the yield of the undesirable metastable isotopic impurity 177 m Lu. The results showed that it was found to be lower than our detection limit i.e. < 0.0005% of 177 g Lu yield. Thick target yields for all detected radionuclides are also calculated in this paper. These measurements enabled the estimation of the production yield and isotopic purity of 177Lu obtained via deuteron-induced nuclear reactions for large production batches using highly enriched 176Yb 2 O 3 samples (> 99.5%). • Cross-section measurement of the theranostic radioisotope 177Lu induced by deuterons up to 33 MeV. • Metastable impurity 177 m Lu below the detection limit (< 0.0005% of 177 g Lu yield). • Production yields and isotopic purities estimated from enriched 176Yb 2 O 3 samples (> 99.5%). [ABSTRACT FROM AUTHOR]
Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Activation cross-sections of lutetium and ytterbium radionuclides have been measured by deuteron-induced nuclear reaction on n a t Yb(d,x) at the GIP ARRONAX (Saint-Herblain, France) cyclotron facility with a beam energy up to 33 MeV using the stacked-foil activation technique combined with high resolution γ -ray spectrometry. The measured experimental values enable the extension of the cross-section to higher energies. As a primary objective, we have focused on the cumulative measurement of the direct and indirect production routes of the therapeutic radioisotope 177 g Lu, via 176Yb(d,n) 177 g , m Lu and 176Yb(d,p) 177Yb → 177 g Lu respectively. Post-irradiation gamma analysis, including a long gamma counting period, was performed to calculate the yield of the undesirable metastable isotopic impurity 177 m Lu. The results showed that it was found to be lower than our detection limit i.e. &lt; 0.0005% of 177 g Lu yield. Thick target yields for all detected radionuclides are also calculated in this paper. These measurements enabled the estimation of the production yield and isotopic purity of 177Lu obtained via deuteron-induced nuclear reactions for large production batches using highly enriched 176Yb 2 O 3 samples (&gt; 99.5%). • Cross-section measurement of the theranostic radioisotope 177Lu induced by deuterons up to 33 MeV. • Metastable impurity 177 m Lu below the detection limit (&lt; 0.0005% of 177 g Lu yield). • Production yields and isotopic purities estimated from enriched 176Yb 2 O 3 samples (&gt; 99.5%). [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Applied Radiation &amp; Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.apradiso.2025.112263
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      – Code: eng
        Text: English
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        StartPage: N.PAG
    Subjects:
      – SubjectFull: Deuteron reactions
        Type: general
      – SubjectFull: Radioisotopes
        Type: general
      – SubjectFull: Metastable states
        Type: general
      – SubjectFull: Isotope separation
        Type: general
      – SubjectFull: Nuclear activation analysis
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      – SubjectFull: Gamma ray spectrometry
        Type: general
      – SubjectFull: Nuclear medicine
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      – TitleFull: Deuteron-induced nuclear reactions to produce 177Lu: Extension of cross-sections data up to 33 MeV and impact on purity.
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            – D: 01
              M: 01
              Text: Jan2026
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              Y: 2026
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