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Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties.

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Title: Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties.
Authors: Wold EA; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States., Garcia EJ; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States., Wild CT; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States., Miszkiel JM; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States., Soto CA; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States., Chen J; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States., Pazdrak K; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States., Fox RG; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States., Anastasio NC; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States., Cunningham KA; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States., Zhou J; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2020 Jul 23; Vol. 63 (14), pp. 7529-7544. Date of Electronic Publication: 2020 Jul 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT<subscript>2C</subscript> Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties.
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  Data: <searchLink fieldCode="AU" term="%22Wold+EA%22">Wold EA</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Garcia+EJ%22">Garcia EJ</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Wild+CT%22">Wild CT</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Miszkiel+JM%22">Miszkiel JM</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Soto+CA%22">Soto CA</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Pazdrak+K%22">Pazdrak K</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Fox+RG%22">Fox RG</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Anastasio+NC%22">Anastasio NC</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Cunningham+KA%22">Cunningham KA</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Center for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.; Chemical Biology Program and the Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2020 Jul 23; Vol. 63 (14), pp. 7529-7544. <i>Date of Electronic Publication: </i>2020 Jul 07.
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        Value: 10.1021/acs.jmedchem.9b01953
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              Text: 2020 Jul 23
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