The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial in healthy volunteers.

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Title: The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial in healthy volunteers.
Authors: Messaoudene M; Axe Cancer, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada., Ferreira S; Da Volterra, Paris, France., Saint-Lu N; Da Volterra, Paris, France., Ponce M; Axe Cancer, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada., Truntzer C; Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-Unicancer, Dijon, France.; UMR INSERM 1231, Dijon, France., Boidot R; Molecular Biology, Georges François Leclerc Cancer Center-Unicancer, Dijon, France., Le Bescop C; Da Volterra, Paris, France., Loppinet T; Da Volterra, Paris, France., Corbel T; Da Volterra, Paris, France., Féger C; Da Volterra, Paris, France.; Medical, EMI Biotech, Paris, France., Bertrand K; Da Volterra, Paris, France., Elkrief A; Axe Cancer, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.; Hemato-Oncology Division, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada., Isaksen M; Bio-Me, Oslo, Norway., Vitry F; Da Volterra, Paris, France., Sablier-Gallis F; Da Volterra, Paris, France., Andremont A; Da Volterra, Paris, France., Bod L; Krantz Family Cancer Center, Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ghiringhelli F; Department of Medical Oncology, Georges François Leclerc Cancer Center-Unicancer, Dijon, France., de Gunzburg J; Da Volterra, Paris, France., Routy B; Axe Cancer, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada. Bertrand.routy@umontreal.ca.; Hemato-Oncology Division, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada. Bertrand.routy@umontreal.ca.
Source: Nature communications [Nat Commun] 2024 Sep 15; Vol. 15 (1), pp. 8083. Date of Electronic Publication: 2024 Sep 15.
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial in healthy volunteers.
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  Data: <searchLink fieldCode="AU" term="%22Messaoudene+M%22">Messaoudene M</searchLink>; Axe Cancer, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Ferreira+S%22">Ferreira S</searchLink>; Da Volterra, Paris, France.<br /><searchLink fieldCode="AU" term="%22Saint-Lu+N%22">Saint-Lu N</searchLink>; Da Volterra, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ponce+M%22">Ponce M</searchLink>; Axe Cancer, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Truntzer+C%22">Truntzer C</searchLink>; Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-Unicancer, Dijon, France.; UMR INSERM 1231, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Boidot+R%22">Boidot R</searchLink>; Molecular Biology, Georges François Leclerc Cancer Center-Unicancer, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Le+Bescop+C%22">Le Bescop C</searchLink>; Da Volterra, Paris, France.<br /><searchLink fieldCode="AU" term="%22Loppinet+T%22">Loppinet T</searchLink>; Da Volterra, Paris, France.<br /><searchLink fieldCode="AU" term="%22Corbel+T%22">Corbel T</searchLink>; Da Volterra, Paris, France.<br /><searchLink fieldCode="AU" term="%22Féger+C%22">Féger C</searchLink>; Da Volterra, Paris, France.; Medical, EMI Biotech, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bertrand+K%22">Bertrand K</searchLink>; Da Volterra, Paris, France.<br /><searchLink fieldCode="AU" term="%22Elkrief+A%22">Elkrief A</searchLink>; Axe Cancer, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.; Hemato-Oncology Division, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Isaksen+M%22">Isaksen M</searchLink>; Bio-Me, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Vitry+F%22">Vitry F</searchLink>; Da Volterra, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sablier-Gallis+F%22">Sablier-Gallis F</searchLink>; Da Volterra, Paris, France.<br /><searchLink fieldCode="AU" term="%22Andremont+A%22">Andremont A</searchLink>; Da Volterra, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bod+L%22">Bod L</searchLink>; Krantz Family Cancer Center, Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ghiringhelli+F%22">Ghiringhelli F</searchLink>; Department of Medical Oncology, Georges François Leclerc Cancer Center-Unicancer, Dijon, France.<br /><searchLink fieldCode="AU" term="%22de+Gunzburg+J%22">de Gunzburg J</searchLink>; Da Volterra, Paris, France.<br /><searchLink fieldCode="AU" term="%22Routy+B%22">Routy B</searchLink>; Axe Cancer, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada. Bertrand.routy@umontreal.ca.; Hemato-Oncology Division, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada. Bertrand.routy@umontreal.ca.
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