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AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models.

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Title: AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models.
Authors: Greer-Short A; Tenaya Therapeutics, South San Francisco, CA, USA., Greenwood A; Tenaya Therapeutics, South San Francisco, CA, USA., Leon EC; Tenaya Therapeutics, South San Francisco, CA, USA., Qureshi TN; Tenaya Therapeutics, South San Francisco, CA, USA., von Kraut K; Tenaya Therapeutics, South San Francisco, CA, USA., Wong J; Tenaya Therapeutics, South San Francisco, CA, USA., Tsui JH; Tenaya Therapeutics, South San Francisco, CA, USA., Reid CA; Tenaya Therapeutics, South San Francisco, CA, USA., Cheng Z; Tenaya Therapeutics, South San Francisco, CA, USA., Easter E; Tenaya Therapeutics, South San Francisco, CA, USA., Yang J; Tenaya Therapeutics, South San Francisco, CA, USA., Ho J; Tenaya Therapeutics, South San Francisco, CA, USA., Steltzer S; Tenaya Therapeutics, South San Francisco, CA, USA., Budan A; Tenaya Therapeutics, South San Francisco, CA, USA., Cho M; Tenaya Therapeutics, South San Francisco, CA, USA., Chandrakumar R; Tenaya Therapeutics, South San Francisco, CA, USA., Cisne-Thompson O; Tenaya Therapeutics, South San Francisco, CA, USA., Feathers C; Tenaya Therapeutics, South San Francisco, CA, USA., Chung TW; Tenaya Therapeutics, South San Francisco, CA, USA., Rodriguez N; Tenaya Therapeutics, South San Francisco, CA, USA., Jones S; Tenaya Therapeutics, South San Francisco, CA, USA., Alleyne-Levy C; Tenaya Therapeutics, South San Francisco, CA, USA., Liu J; Tenaya Therapeutics, South San Francisco, CA, USA., Jing F; Tenaya Therapeutics, South San Francisco, CA, USA., Prince WS; Tenaya Therapeutics, South San Francisco, CA, USA., Lin J; Tenaya Therapeutics, South San Francisco, CA, USA., Ivey KN; Tenaya Therapeutics, South San Francisco, CA, USA., Tingley WG; Tenaya Therapeutics, South San Francisco, CA, USA., Hoey T; Tenaya Therapeutics, South San Francisco, CA, USA., Lombardi LM; Tenaya Therapeutics, South San Francisco, CA, USA. llombardi@tenayathera.com.
Source: Nature communications [Nat Commun] 2025 Mar 04; Vol. 16 (1), pp. 2196. Date of Electronic Publication: 2025 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models.
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  Data: <searchLink fieldCode="AU" term="%22Greer-Short+A%22">Greer-Short A</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Greenwood+A%22">Greenwood A</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Leon+EC%22">Leon EC</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Qureshi+TN%22">Qureshi TN</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22von+Kraut+K%22">von Kraut K</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wong+J%22">Wong J</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tsui+JH%22">Tsui JH</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Reid+CA%22">Reid CA</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+Z%22">Cheng Z</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Easter+E%22">Easter E</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ho+J%22">Ho J</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Steltzer+S%22">Steltzer S</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Budan+A%22">Budan A</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cho+M%22">Cho M</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chandrakumar+R%22">Chandrakumar R</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cisne-Thompson+O%22">Cisne-Thompson O</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Feathers+C%22">Feathers C</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chung+TW%22">Chung TW</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+N%22">Rodriguez N</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jones+S%22">Jones S</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Alleyne-Levy+C%22">Alleyne-Levy C</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jing+F%22">Jing F</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Prince+WS%22">Prince WS</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ivey+KN%22">Ivey KN</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tingley+WG%22">Tingley WG</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hoey+T%22">Hoey T</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lombardi+LM%22">Lombardi LM</searchLink>; Tenaya Therapeutics, South San Francisco, CA, USA. llombardi@tenayathera.com.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Mar 04; Vol. 16 (1), pp. 2196. <i>Date of Electronic Publication: </i>2025 Mar 04.
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