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Clinical heterogeneity and treatment outcomes of extrapulmonary tuberculosis in a low-incidence setting: insights from a prospective cohort study.

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Title: Clinical heterogeneity and treatment outcomes of extrapulmonary tuberculosis in a low-incidence setting: insights from a prospective cohort study.
Authors: Klingmüller A; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany., Feldmann M; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; Department of Internal Medicine, Evangelisches Krankenhaus Düsseldorf, Düsseldorf, Germany., Rohr S; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Orthopedics and Trauma surgery, Bundeswehr Central Hospital Koblenz, Koblenz, Germany., Helmhold L; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Junker L; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Scherer M; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Faculty of Medicine, Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Frankfurt, Germany., Vehreschild JJ; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany.; Faculty of Medicine, Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Frankfurt, Germany., Schmidt-Hellerau K; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Hoffmann A; Institute for Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne, Cologne, Germany., Jantsch J; Institute for Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne, Cologne, Germany., Simonis A; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany., Suárez V; Department II of Internal Medicine (Nephrology, Rheumatology, Diabetes, and General Internal Medicine, Center for Molecular Medicine Cologne, Cologne, Germany.; Emergency Department, University of Cologne, Cologne, Germany., Rauschning D; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department IB of Internal Medicine, Bundeswehr Central Hospital Koblenz, Koblenz, Germany., Funke N; Municipal Health Authority Cologne, Cologne, Germany., Malin JJ; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany., Biehl LM; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany., Schommers P; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany., Fätkenheuer G; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany., Lehmann C; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany., Rybniker J; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. jan.rybniker@uk-koeln.de.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany. jan.rybniker@uk-koeln.de.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany. jan.rybniker@uk-koeln.de., Suárez I; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. isabelle.suarez@uk-koeln.de.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany. isabelle.suarez@uk-koeln.de.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany. isabelle.suarez@uk-koeln.de.
Source: Infection [Infection] 2025 Oct; Vol. 53 (5), pp. 1809-1818. Date of Electronic Publication: 2025 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Heidelberg Country of Publication: Germany NLM ID: 0365307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0973 (Electronic) Linking ISSN: 03008126 NLM ISO Abbreviation: Infection Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical heterogeneity and treatment outcomes of extrapulmonary tuberculosis in a low-incidence setting: insights from a prospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Klingmüller+A%22">Klingmüller A</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Feldmann+M%22">Feldmann M</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; Department of Internal Medicine, Evangelisches Krankenhaus Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Rohr+S%22">Rohr S</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Orthopedics and Trauma surgery, Bundeswehr Central Hospital Koblenz, Koblenz, Germany.<br /><searchLink fieldCode="AU" term="%22Helmhold+L%22">Helmhold L</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Junker+L%22">Junker L</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Scherer+M%22">Scherer M</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Faculty of Medicine, Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Vehreschild+JJ%22">Vehreschild JJ</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany.; Faculty of Medicine, Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt-Hellerau+K%22">Schmidt-Hellerau K</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+A%22">Hoffmann A</searchLink>; Institute for Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Jantsch+J%22">Jantsch J</searchLink>; Institute for Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Simonis+A%22">Simonis A</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Suárez+V%22">Suárez V</searchLink>; Department II of Internal Medicine (Nephrology, Rheumatology, Diabetes, and General Internal Medicine, Center for Molecular Medicine Cologne, Cologne, Germany.; Emergency Department, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Rauschning+D%22">Rauschning D</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department IB of Internal Medicine, Bundeswehr Central Hospital Koblenz, Koblenz, Germany.<br /><searchLink fieldCode="AU" term="%22Funke+N%22">Funke N</searchLink>; Municipal Health Authority Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Malin+JJ%22">Malin JJ</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Biehl+LM%22">Biehl LM</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Schommers+P%22">Schommers P</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Fätkenheuer+G%22">Fätkenheuer G</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Lehmann+C%22">Lehmann C</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Rybniker+J%22">Rybniker J</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. jan.rybniker@uk-koeln.de.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany. jan.rybniker@uk-koeln.de.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany. jan.rybniker@uk-koeln.de.<br /><searchLink fieldCode="AU" term="%22Suárez+I%22">Suárez I</searchLink>; Department I of Internal Medicine, Division of Infectious Diseases, Medical Faculty and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. isabelle.suarez@uk-koeln.de.; Center for Molecular Medicine Cologne (CMMC), Medical Faculty and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany. isabelle.suarez@uk-koeln.de.; German Center for Infection Research (DZIF), Bonn-Cologne, Germany. isabelle.suarez@uk-koeln.de.
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