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Methionine sulfoxide reductase A deficiency aggravated ferroptosis in LPS-induced acute kidney injury by inhibiting the AMPK/NRF2 axis and activating the CaMKII/HIF-1α pathway.

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Title: Methionine sulfoxide reductase A deficiency aggravated ferroptosis in LPS-induced acute kidney injury by inhibiting the AMPK/NRF2 axis and activating the CaMKII/HIF-1α pathway.
Authors: Yang L; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China., Xiao JJ; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China; Department of Cardiology, Zhongnan Hospital of Wuhan University, Institute of Myocardial Injury and Repair, Wuhan University, Wuhan, 430071, China., Zhang L; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China., Lu Q; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China., Hu BB; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China., Liu Y; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China., Pu JX; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China., Hu JW; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China., Yu H; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China. Electronic address: yu.hong@whu.edu.cn., Wu X; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: wuxiaoyan2k6@whu.edu.cn., Zhang BF; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China. Electronic address: zbfwq@whu.edu.cn.
Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Jul; Vol. 234, pp. 248-263. Date of Electronic Publication: 2025 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Methionine sulfoxide reductase A deficiency aggravated ferroptosis in LPS-induced acute kidney injury by inhibiting the AMPK/NRF2 axis and activating the CaMKII/HIF-1α pathway.
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  Data: <searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Xiao+JJ%22">Xiao JJ</searchLink>; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China; Department of Cardiology, Zhongnan Hospital of Wuhan University, Institute of Myocardial Injury and Repair, Wuhan University, Wuhan, 430071, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Lu+Q%22">Lu Q</searchLink>; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Hu+BB%22">Hu BB</searchLink>; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Pu+JX%22">Pu JX</searchLink>; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Hu+JW%22">Hu JW</searchLink>; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China. Electronic address: yu.hong@whu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: wuxiaoyan2k6@whu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+BF%22">Zhang BF</searchLink>; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China. Electronic address: zbfwq@whu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228709159%22">Free radical biology & medicine</searchLink> [Free Radic Biol Med] 2025 Jul; Vol. 234, pp. 248-263. <i>Date of Electronic Publication: </i>2025 Apr 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8709159 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-4596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208915849%22">08915849 </searchLink><i>NLM ISO Abbreviation: </i>Free Radic Biol Med <i>Subsets: </i>MEDLINE
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              Text: 2025 Jul
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