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Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial.

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Title: Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial.
Authors: Jeyanathan M; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada., Afkhami S; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON, Canada., D'Agostino MR; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Satia I; Department of Medicine, McMaster University, Hamilton, ON, Canada., Fritz DK; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada., Miyasaki K; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada., Ang JC; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Zganiacz A; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada., Howie KJ; Department of Medicine, McMaster University, Hamilton, ON, Canada., Swinton M; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.; Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada., Aguirre E; Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada., Zheng MB; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada., Kazhdan N; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada., Dvorkin-Gheva A; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada., Mbuagbaw L; Department of Health Research Methodology, Evidence and Impact, McMaster University, Hamilton, ON, Canada., Medina MFC; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada., Diab N; Department of Medicine, McMaster University, Hamilton, ON, Canada., Brister DL; Department of Medicine, McMaster University, Hamilton, ON, Canada., Gauvreau GM; Department of Medicine, McMaster University, Hamilton, ON, Canada., Lichty BD; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. lichtyb@mcmaster.ca.; Department of Medicine, McMaster University, Hamilton, ON, Canada. lichtyb@mcmaster.ca.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada. lichtyb@mcmaster.ca., Miller MS; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. mmiller@mcmaster.ca.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada. mmiller@mcmaster.ca.; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON, Canada. mmiller@mcmaster.ca., Smaill F; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. smaill@mcmaster.ca.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada. smaill@mcmaster.ca.; Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada. smaill@mcmaster.ca., Xing Z; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. xingz@mcmaster.ca.; Department of Medicine, McMaster University, Hamilton, ON, Canada. xingz@mcmaster.ca.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada. xingz@mcmaster.ca.
Source: Nature communications [Nat Commun] 2025 Jul 02; Vol. 16 (1), pp. 6000. Date of Electronic Publication: 2025 Jul 02.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Jeyanathan+M%22">Jeyanathan M</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Afkhami+S%22">Afkhami S</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22D'Agostino+MR%22">D'Agostino MR</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Satia+I%22">Satia I</searchLink>; Department of Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Fritz+DK%22">Fritz DK</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Miyasaki+K%22">Miyasaki K</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ang+JC%22">Ang JC</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Zganiacz+A%22">Zganiacz A</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Howie+KJ%22">Howie KJ</searchLink>; Department of Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Swinton+M%22">Swinton M</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.; Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Aguirre+E%22">Aguirre E</searchLink>; Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Zheng+MB%22">Zheng MB</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kazhdan+N%22">Kazhdan N</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dvorkin-Gheva+A%22">Dvorkin-Gheva A</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mbuagbaw+L%22">Mbuagbaw L</searchLink>; Department of Health Research Methodology, Evidence and Impact, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Medina+MFC%22">Medina MFC</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Diab+N%22">Diab N</searchLink>; Department of Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Brister+DL%22">Brister DL</searchLink>; Department of Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Gauvreau+GM%22">Gauvreau GM</searchLink>; Department of Medicine, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lichty+BD%22">Lichty BD</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. lichtyb@mcmaster.ca.; Department of Medicine, McMaster University, Hamilton, ON, Canada. lichtyb@mcmaster.ca.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada. lichtyb@mcmaster.ca.<br /><searchLink fieldCode="AU" term="%22Miller+MS%22">Miller MS</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. mmiller@mcmaster.ca.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada. mmiller@mcmaster.ca.; Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON, Canada. mmiller@mcmaster.ca.<br /><searchLink fieldCode="AU" term="%22Smaill+F%22">Smaill F</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. smaill@mcmaster.ca.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada. smaill@mcmaster.ca.; Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada. smaill@mcmaster.ca.<br /><searchLink fieldCode="AU" term="%22Xing+Z%22">Xing Z</searchLink>; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. xingz@mcmaster.ca.; Department of Medicine, McMaster University, Hamilton, ON, Canada. xingz@mcmaster.ca.; Global Nexus School for Pandemic Prevention and Response, McMaster University, Hamilton, ON, Canada. xingz@mcmaster.ca.
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