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Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies.

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Title: Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies.
Authors: Lederhofer J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Borst AJ; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA., Nguyen L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Gillespie RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Williams CJ; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA., Walker EL; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA., Raab JE; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Yap C; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Ellis D; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.; Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA, 98195, USA., Creanga A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Tan HX; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia., Do THT; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia., Ravichandran M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., McDermott AB; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Le Sage V; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA., Andrews SF; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Graham BS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Wheatley AK; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia., Reed DS; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA., King NP; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA. neilking@uw.edu.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA. neilking@uw.edu., Kanekiyo M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. kanekiyom@nih.gov.
Source: Nature communications [Nat Commun] 2025 Aug 01; Vol. 16 (1), pp. 7068. Date of Electronic Publication: 2025 Aug 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies.
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  Data: <searchLink fieldCode="AU" term="%22Lederhofer+J%22">Lederhofer J</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Borst+AJ%22">Borst AJ</searchLink>; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+L%22">Nguyen L</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Gillespie+RA%22">Gillespie RA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Williams+CJ%22">Williams CJ</searchLink>; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Walker+EL%22">Walker EL</searchLink>; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Raab+JE%22">Raab JE</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Yap+C%22">Yap C</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Ellis+D%22">Ellis D</searchLink>; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.; Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Creanga+A%22">Creanga A</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Tan+HX%22">Tan HX</searchLink>; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Do+THT%22">Do THT</searchLink>; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Ravichandran+M%22">Ravichandran M</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22McDermott+AB%22">McDermott AB</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Le+Sage+V%22">Le Sage V</searchLink>; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Andrews+SF%22">Andrews SF</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Graham+BS%22">Graham BS</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Wheatley+AK%22">Wheatley AK</searchLink>; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Reed+DS%22">Reed DS</searchLink>; Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22King+NP%22">King NP</searchLink>; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA. neilking@uw.edu.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA. neilking@uw.edu.<br /><searchLink fieldCode="AU" term="%22Kanekiyo+M%22">Kanekiyo M</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. kanekiyom@nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Aug 01; Vol. 16 (1), pp. 7068. <i>Date of Electronic Publication: </i>2025 Aug 01.
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