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Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties.

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Title: Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties.
Authors: Aaen KH; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway., Testa MF; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Nilsen J; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway., Tarantino R; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Canepari C; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Benedusi M; Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy., Benjakul S; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway., Nyquist-Andersen M; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway., Herigstad ML; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway., Cantore A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Valacchi G; Department of Environmental Sciences and Prevention, University of Ferrara, Ferrara, Italy.; Department of Neurosciences and Rehabilitation; Animal Science Department, NC Research Campus, Plants for Human Health Institute, NC State University, Kannapolis, NC, USA.; Department of Food and Nutrition, Kyung Hee University, Seoul, Republic of Korea., Sandlie I; Department of Biosciences, University of Oslo, Oslo, Norway., Bernardi F; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Pinotti M; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Branchini A; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. brnlss@unife.it., Andersen JT; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway. j.t.andersen@medisin.uio.no.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway. j.t.andersen@medisin.uio.no.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway. j.t.andersen@medisin.uio.no.
Source: Nature communications [Nat Commun] 2025 Sep 29; Vol. 16 (1), pp. 8433. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties.
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  Data: <searchLink fieldCode="AU" term="%22Aaen+KH%22">Aaen KH</searchLink>; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Testa+MF%22">Testa MF</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Nilsen+J%22">Nilsen J</searchLink>; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Tarantino+R%22">Tarantino R</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Canepari+C%22">Canepari C</searchLink>; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Benedusi+M%22">Benedusi M</searchLink>; Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Benjakul+S%22">Benjakul S</searchLink>; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Nyquist-Andersen+M%22">Nyquist-Andersen M</searchLink>; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Herigstad+ML%22">Herigstad ML</searchLink>; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Cantore+A%22">Cantore A</searchLink>; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Valacchi+G%22">Valacchi G</searchLink>; Department of Environmental Sciences and Prevention, University of Ferrara, Ferrara, Italy.; Department of Neurosciences and Rehabilitation; Animal Science Department, NC Research Campus, Plants for Human Health Institute, NC State University, Kannapolis, NC, USA.; Department of Food and Nutrition, Kyung Hee University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Sandlie+I%22">Sandlie I</searchLink>; Department of Biosciences, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Bernardi+F%22">Bernardi F</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Pinotti+M%22">Pinotti M</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Branchini+A%22">Branchini A</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. brnlss@unife.it.<br /><searchLink fieldCode="AU" term="%22Andersen+JT%22">Andersen JT</searchLink>; Institute of Clinical Medicine, Department of Pharmacology, University of Oslo, Oslo, Norway. j.t.andersen@medisin.uio.no.; Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway. j.t.andersen@medisin.uio.no.; Precision Immunotherapy Alliance (PRIMA), University of Oslo, Oslo, Norway. j.t.andersen@medisin.uio.no.
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