Anti-progestin therapy targets hallmarks of breast cancer risk.
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| Title: | Anti-progestin therapy targets hallmarks of breast cancer risk. |
|---|---|
| Authors: | Simões BM; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. bruno.simoes@manchester.ac.uk., Pedley R; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK.; Medicines Discovery Catapult, Alderley Park, Cheshire, UK., McCloskey CW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Roberts M; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Reed AD; Department of Pharmacology, University of Cambridge and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Twigger AJ; Department of Pharmacology, University of Cambridge and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Tharmapalan P; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Caruso A; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Department of Pharmacy, Health and Nutritional Sciences, Health Center, University of Calabria, Cosenza, Italy., Cabral S; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Wilby AJ; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Harrison H; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Zhou Y; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK., Greenhalgh A; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Alghamdi SA; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Forestiero M; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Department of Pharmacy, Health and Nutritional Sciences, Health Center, University of Calabria, Cosenza, Italy., Lopez-Muñoz J; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Roche J; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Tuieng RJ; Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Khan MA; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK., Squires S; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Astley SM; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Harkness EF; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Santiago-Gómez A; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Spence K; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Ritchie J; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK., Pritchard S; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK., Lim Y; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK., Sherratt MJ; Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Andò S; Department of Pharmacy, Health and Nutritional Sciences, Health Center, University of Calabria, Cosenza, Italy., Howell A; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK., Evans DG; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.; Manchester Centre for Genomic Medicine, Division of Evolution, Infection and Genomic Health, University of Manchester and St Mary's Hospital, Manchester, UK., Gilmore AP; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK., Khaled WT; Department of Pharmacology, University of Cambridge and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Khokha R; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Clarke RB; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. robert.clarke@manchester.ac.uk., Howell SJ; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. sacha.howell@nhs.net.; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK. sacha.howell@nhs.net.; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK. sacha.howell@nhs.net. |
| Source: | Nature [Nature] 2025 Dec; Vol. 648 (8094), pp. 736-745. Date of Electronic Publication: 2025 Nov 05. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41193807 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Anti-progestin therapy targets hallmarks of breast cancer risk. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Simões+BM%22">Simões BM</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. bruno.simoes@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Pedley+R%22">Pedley R</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK.; Medicines Discovery Catapult, Alderley Park, Cheshire, UK.<br /><searchLink fieldCode="AU" term="%22McCloskey+CW%22">McCloskey CW</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+M%22">Roberts M</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Reed+AD%22">Reed AD</searchLink>; Department of Pharmacology, University of Cambridge and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Twigger+AJ%22">Twigger AJ</searchLink>; Department of Pharmacology, University of Cambridge and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tharmapalan+P%22">Tharmapalan P</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Caruso+A%22">Caruso A</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Department of Pharmacy, Health and Nutritional Sciences, Health Center, University of Calabria, Cosenza, Italy.<br /><searchLink fieldCode="AU" term="%22Cabral+S%22">Cabral S</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Wilby+AJ%22">Wilby AJ</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Harrison+H%22">Harrison H</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Greenhalgh+A%22">Greenhalgh A</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Alghamdi+SA%22">Alghamdi SA</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Forestiero+M%22">Forestiero M</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Department of Pharmacy, Health and Nutritional Sciences, Health Center, University of Calabria, Cosenza, Italy.<br /><searchLink fieldCode="AU" term="%22Lopez-Muñoz+J%22">Lopez-Muñoz J</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Roche+J%22">Roche J</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Tuieng+RJ%22">Tuieng RJ</searchLink>; Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Khan+MA%22">Khan MA</searchLink>; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Squires+S%22">Squires S</searchLink>; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Astley+SM%22">Astley SM</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Harkness+EF%22">Harkness EF</searchLink>; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Santiago-Gómez+A%22">Santiago-Gómez A</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Spence+K%22">Spence K</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Ritchie+J%22">Ritchie J</searchLink>; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Pritchard+S%22">Pritchard S</searchLink>; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Lim+Y%22">Lim Y</searchLink>; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Sherratt+MJ%22">Sherratt MJ</searchLink>; Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Andò+S%22">Andò S</searchLink>; Department of Pharmacy, Health and Nutritional Sciences, Health Center, University of Calabria, Cosenza, Italy.<br /><searchLink fieldCode="AU" term="%22Howell+A%22">Howell A</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Evans+DG%22">Evans DG</searchLink>; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.; Manchester Centre for Genomic Medicine, Division of Evolution, Infection and Genomic Health, University of Manchester and St Mary's Hospital, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Gilmore+AP%22">Gilmore AP</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Cell-Matrix Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Khaled+WT%22">Khaled WT</searchLink>; Department of Pharmacology, University of Cambridge and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Khokha+R%22">Khokha R</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Clarke+RB%22">Clarke RB</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. robert.clarke@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Howell+SJ%22">Howell SJ</searchLink>; Manchester Breast Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. sacha.howell@nhs.net.; Nightingale and Prevent Breast Cancer Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK. sacha.howell@nhs.net.; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK. sacha.howell@nhs.net. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2025 Dec; Vol. 648 (8094), pp. 736-745. <i>Date of Electronic Publication: </i>2025 Nov 05. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0410462 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4687 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200280836%22">00280836 </searchLink><i>NLM ISO Abbreviation: </i>Nature <i>Subsets: </i>MEDLINE |
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