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Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET).

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Title: Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET).
Authors: Spada F; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Gelsomino F; Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy., Rinzivillo M; Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, ENETS Center of Excellence, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy., Cinquini M; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Fittipaldo VA; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Tralongo A; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Moschetti I; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Albertelli M; Endocrine Unit, Department of Internal Medicine & Medical Specialties, University of Genova, Genova, Italy; Endocrine Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Ambrosini V; Nuclear Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy; Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria, Bologna, Italy., Amoroso V; Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy., Antonuzzo L; Clinical Oncology Unit, Careggi University Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Medical Oncology Unit, Careggi University Hospital, Florence, Italy., Badalamenti G; Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy., Bajetta E; Istituto di Oncologia, Policlinico di Monza, Monza, Italy., Baldari S; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy., Barberis M; Division of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy., Berruti A; Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy., Bertani E; Division of Digestive Surgery IEO, European Institute of Oncology, IEO, IRCCS, ENETS and Center of Excellence, Milan, Italy., Bonomo G; Department of Interventional Radiology, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Bodei L; Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA., Buzzoni R; Department of Medical Oncology, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy., Brizzi MP; Department of Oncology, 'San Luigi Gonzaga' University Hospital, University of Turin, Orbassano, Italy., Campana D; Department of Experimental Diagnostic and Specialized Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS Azienda Ospedaliera-Universitaria, Neuroendocrine Tumor Team Bologna, Bologna, Italy., Capurso G; Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, ENETS Center of Excellence, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy., Casadei R; Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy., Castellano M; Department of Internal Medicine and Endocrinology, University of Brescia, ASST Spedali Civili, Brescia, Italy., Cingarlini S; Department of Medicine, Oncology, University and Hospital Trust of Verona, ENETS Center of Excellence, Verona, Italy., Cives M; Interdisciplinary Department of Medicine, University 'Aldo Moro', Bari, Italy; Medical Oncology, AOU Consorziale Policlinico di Bari, Bari, Italy., Colao AM; Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy; UNESCO Chair on Health Education and Sustainable Development, Federico II University, Naples, Italy., Coppa J; Gastro-entero-pancreatic Surgical and Liver Transplantation Unit, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy., Cremonini N; Endocrinology Clinics, Clinica Villalba, Bologna, Italy., Davì MV; Department of Medicine, Section of Endocrinology, University and Hospital Trust of Verona, ENETS Center of Excellence, Verona, Italy., De Angelis CG; Gastroenterology and Digestive Endoscopy Unit, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy., de Braud F; Department of Medical Oncology, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy; Department of Oncology and Hemato-Oncology, Università deli Studi di Milano, Milan, Italy., De Robertis R; Department of Radiology, G.B. Rossi Hospital, University of Verona, Verona, Italy., Faggiano A; Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy., Falconi M; Pancreatic Surgery, Pancreas Translational and Clinical Research Center, San Raffaele Hospital IRCCS, Università Vita-Salute San Raffaele, ENETS Center of Excellence, Milan, Italy., Fassan M; Department of Medicine (DIMED), University of Padova, Padova, Italy; Veneto Institute of Oncology IOV-IRCCS, Padova, Italy., Ferolla P; NET Multidisciplinary Group, Umbria Regional Cancer Network, Perugia, Italy., Ferone D; Endocrine Unit, Department of Internal Medicine & Medical Specialties, University of Genova, Genova, Italy; Endocrine Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Filice A; Nuclear Medicine Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Fiore F; Onco Interventional Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy., Funicelli L; Division of Radiology, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Granata V; Division of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy., Giuffrida D; Oncologia Medica, Istituto Oncologico del Mediterraneo, Viagrande, Catania, Italy., Grana CM; Division of Nuclear Medicine, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Grimaldi F; AME Past President, Udine, Italy., Ibrahim T; Osteoncology and Rare Tumor Center (CDO-TR), IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., La Salvia A; National Center for Drug Research and Evaluation, National Institute of Health (Istituto Superiore di Sanità, ISS), Rome, Italy., Laghi A; Department of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome-Radiology Unit-Sant'Andrea University Hospital, Rome, Italy., Luppi G; Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy., Maccauro M; Department of Nuclear Medicine, IRCCS Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy., Marconcini R; Department of Medical Oncology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy., Massironi S; Fondazione IRCCS Policlinico, Divisione Gastroenterologia ed Endoscopia Digestiva, Milan, Italy., Mazzaferro V; Gastro-entero-pancreatic Surgical and Liver Transplantation Unit, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Merola E; Gastroenterology and Digestive Endoscopy Unit, Santa Chiara Hospital, Trento, Italy., Milione M; First Division of Pathology, Department of Pathology and Laboratory Medicine, IRCCS Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy., Modica R; Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy., Ortolani S; Department of Oncology, Ospedale P. Pederzoli, Peschiera del Garda, Italy., Papotti MG; Unit of Pathology, Città della Salute e della Scienza, Turin, Italy; Department of Oncology, University of Turin, Turin, Italy., Partelli S; Pancreatic Surgery, Pancreas Translational and Clinical Research Center, San Raffaele Hospital IRCCS, Università Vita-Salute San Raffaele, ENETS Center of Excellence, Milan, Italy., Pelosi G; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Pusceddu S; Department of Medical Oncology, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy., Ramundo V; Departments of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy., Ravizza D; Division of Endoscopy, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Razzore P; SC Endocrinologia, Diabetologia e Malattie del Metabolismo, AO Ordine Mauriziano, Turin, Italy., Reimondo G; Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy., Ricci C; Division of Pancreatic Surgery, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Rindi G; Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; Anatomic Pathology Unit, Department of Woman and Child Health Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli-IRCCS, ENETS Center of Excellence, Rome, Italy., Rizzo FM; Oncology and Breast Unit, Ospedale 'A. Perrino', Brindisi, Italy., Rossi RE; Gastroenterology and Endoscopy Unit, IRCCS Humanitas Research Hospital, ENETS Center of Excellence, Milan, Italy., Tafuto S; Oncologia Clinica e Sperimentale Sarcomi e Tumori Rari, Istituto Nazionale Tumori IRCCS Fondazione Pascale, ENETS Center of Excellence, Naples, Italy., Tiberio GAM; General Surgery, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili, Brescia, Italy., Versari A; Nuclear Medicine Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Vigorito R; Division of Radiology, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy., Zatelli MC; Department of Medical Sciences, Section of Endocrinology, Geriatrics and Internal Medicine, University of Ferrara, Ferrara, Italy., Di Maio M; Department of Oncology, University of Turin, A.O. Ordine Mauriziano, Turin, Italy., Perrone F; Clinical Trial Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy., Cinieri S; Oncology and Breast Unit, Ospedale 'A. Perrino', Brindisi, Italy., Panzuto F; Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, ENETS Center of Excellence, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy. Electronic address: francesco.panzuto@uniroma1.it., Fazio N; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy. Electronic address: nicola.fazio@ieo.it.
Source: ESMO open [ESMO Open] 2025 Nov; Vol. 10 (11), pp. 105878. Date of Electronic Publication: 2025 Nov 12.
Publication Type: Journal Article; Practice Guideline; Review
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
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  Data: Clinical practice guidelines for the management of non-functioning advanced GEP-NENs: a GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology (AIOM) in collaboration with the Italian Association for Neuroendocrine Tumors (ITANET).
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Spada+F%22">Spada F</searchLink>; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gelsomino+F%22">Gelsomino F</searchLink>; Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Rinzivillo+M%22">Rinzivillo M</searchLink>; Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, ENETS Center of Excellence, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cinquini+M%22">Cinquini M</searchLink>; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fittipaldo+VA%22">Fittipaldo VA</searchLink>; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tralongo+A%22">Tralongo A</searchLink>; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Moschetti+I%22">Moschetti I</searchLink>; Department of Clinical Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Albertelli+M%22">Albertelli M</searchLink>; Endocrine Unit, Department of Internal Medicine & Medical Specialties, University of Genova, Genova, Italy; Endocrine Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Ambrosini+V%22">Ambrosini V</searchLink>; Nuclear Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy; Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Amoroso+V%22">Amoroso V</searchLink>; Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Antonuzzo+L%22">Antonuzzo L</searchLink>; Clinical Oncology Unit, Careggi University Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Medical Oncology Unit, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Badalamenti+G%22">Badalamenti G</searchLink>; Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Bajetta+E%22">Bajetta E</searchLink>; Istituto di Oncologia, Policlinico di Monza, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Baldari+S%22">Baldari S</searchLink>; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Barberis+M%22">Barberis M</searchLink>; Division of Experimental Oncology, European Institute of Oncology, IEO, IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Berruti+A%22">Berruti A</searchLink>; Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bertani+E%22">Bertani E</searchLink>; Division of Digestive Surgery IEO, European Institute of Oncology, IEO, IRCCS, ENETS and Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonomo+G%22">Bonomo G</searchLink>; Department of Interventional Radiology, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bodei+L%22">Bodei L</searchLink>; Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Buzzoni+R%22">Buzzoni R</searchLink>; Department of Medical Oncology, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Brizzi+MP%22">Brizzi MP</searchLink>; Department of Oncology, 'San Luigi Gonzaga' University Hospital, University of Turin, Orbassano, Italy.<br /><searchLink fieldCode="AU" term="%22Campana+D%22">Campana D</searchLink>; Department of Experimental Diagnostic and Specialized Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS Azienda Ospedaliera-Universitaria, Neuroendocrine Tumor Team Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Capurso+G%22">Capurso G</searchLink>; Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, ENETS Center of Excellence, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Casadei+R%22">Casadei R</searchLink>; Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Castellano+M%22">Castellano M</searchLink>; Department of Internal Medicine and Endocrinology, University of Brescia, ASST Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Cingarlini+S%22">Cingarlini S</searchLink>; Department of Medicine, Oncology, University and Hospital Trust of Verona, ENETS Center of Excellence, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Cives+M%22">Cives M</searchLink>; Interdisciplinary Department of Medicine, University 'Aldo Moro', Bari, Italy; Medical Oncology, AOU Consorziale Policlinico di Bari, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Colao+AM%22">Colao AM</searchLink>; Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy; UNESCO Chair on Health Education and Sustainable Development, Federico II University, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Coppa+J%22">Coppa J</searchLink>; Gastro-entero-pancreatic Surgical and Liver Transplantation Unit, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cremonini+N%22">Cremonini N</searchLink>; Endocrinology Clinics, Clinica Villalba, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Davì+MV%22">Davì MV</searchLink>; Department of Medicine, Section of Endocrinology, University and Hospital Trust of Verona, ENETS Center of Excellence, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22De+Angelis+CG%22">De Angelis CG</searchLink>; Gastroenterology and Digestive Endoscopy Unit, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22de+Braud+F%22">de Braud F</searchLink>; Department of Medical Oncology, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy; Department of Oncology and Hemato-Oncology, Università deli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Robertis+R%22">De Robertis R</searchLink>; Department of Radiology, G.B. Rossi Hospital, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Faggiano+A%22">Faggiano A</searchLink>; Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Falconi+M%22">Falconi M</searchLink>; Pancreatic Surgery, Pancreas Translational and Clinical Research Center, San Raffaele Hospital IRCCS, Università Vita-Salute San Raffaele, ENETS Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fassan+M%22">Fassan M</searchLink>; Department of Medicine (DIMED), University of Padova, Padova, Italy; Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Ferolla+P%22">Ferolla P</searchLink>; NET Multidisciplinary Group, Umbria Regional Cancer Network, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Ferone+D%22">Ferone D</searchLink>; Endocrine Unit, Department of Internal Medicine & Medical Specialties, University of Genova, Genova, Italy; Endocrine Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Filice+A%22">Filice A</searchLink>; Nuclear Medicine Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Fiore+F%22">Fiore F</searchLink>; Onco Interventional Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Funicelli+L%22">Funicelli L</searchLink>; Division of Radiology, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Granata+V%22">Granata V</searchLink>; Division of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Giuffrida+D%22">Giuffrida D</searchLink>; Oncologia Medica, Istituto Oncologico del Mediterraneo, Viagrande, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Grana+CM%22">Grana CM</searchLink>; Division of Nuclear Medicine, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Grimaldi+F%22">Grimaldi F</searchLink>; AME Past President, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Ibrahim+T%22">Ibrahim T</searchLink>; Osteoncology and Rare Tumor Center (CDO-TR), IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22La+Salvia+A%22">La Salvia A</searchLink>; National Center for Drug Research and Evaluation, National Institute of Health (Istituto Superiore di Sanità, ISS), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Laghi+A%22">Laghi A</searchLink>; Department of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome-Radiology Unit-Sant'Andrea University Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Luppi+G%22">Luppi G</searchLink>; Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Maccauro+M%22">Maccauro M</searchLink>; Department of Nuclear Medicine, IRCCS Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Marconcini+R%22">Marconcini R</searchLink>; Department of Medical Oncology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Massironi+S%22">Massironi S</searchLink>; Fondazione IRCCS Policlinico, Divisione Gastroenterologia ed Endoscopia Digestiva, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mazzaferro+V%22">Mazzaferro V</searchLink>; Gastro-entero-pancreatic Surgical and Liver Transplantation Unit, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Merola+E%22">Merola E</searchLink>; Gastroenterology and Digestive Endoscopy Unit, Santa Chiara Hospital, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Milione+M%22">Milione M</searchLink>; First Division of Pathology, Department of Pathology and Laboratory Medicine, IRCCS Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Modica+R%22">Modica R</searchLink>; Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Ortolani+S%22">Ortolani S</searchLink>; Department of Oncology, Ospedale P. Pederzoli, Peschiera del Garda, Italy.<br /><searchLink fieldCode="AU" term="%22Papotti+MG%22">Papotti MG</searchLink>; Unit of Pathology, Città della Salute e della Scienza, Turin, Italy; Department of Oncology, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Partelli+S%22">Partelli S</searchLink>; Pancreatic Surgery, Pancreas Translational and Clinical Research Center, San Raffaele Hospital IRCCS, Università Vita-Salute San Raffaele, ENETS Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pelosi+G%22">Pelosi G</searchLink>; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pusceddu+S%22">Pusceddu S</searchLink>; Department of Medical Oncology, Foundation National Cancer Institute, ENETS Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ramundo+V%22">Ramundo V</searchLink>; Departments of Clinical Medicine and Surgery, Federico II University, ENETS Center of Excellence, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Ravizza+D%22">Ravizza D</searchLink>; Division of Endoscopy, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Razzore+P%22">Razzore P</searchLink>; SC Endocrinologia, Diabetologia e Malattie del Metabolismo, AO Ordine Mauriziano, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Reimondo+G%22">Reimondo G</searchLink>; Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy.<br /><searchLink fieldCode="AU" term="%22Ricci+C%22">Ricci C</searchLink>; Division of Pancreatic Surgery, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Rindi+G%22">Rindi G</searchLink>; Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; Anatomic Pathology Unit, Department of Woman and Child Health Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli-IRCCS, ENETS Center of Excellence, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rizzo+FM%22">Rizzo FM</searchLink>; Oncology and Breast Unit, Ospedale 'A. Perrino', Brindisi, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+RE%22">Rossi RE</searchLink>; Gastroenterology and Endoscopy Unit, IRCCS Humanitas Research Hospital, ENETS Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tafuto+S%22">Tafuto S</searchLink>; Oncologia Clinica e Sperimentale Sarcomi e Tumori Rari, Istituto Nazionale Tumori IRCCS Fondazione Pascale, ENETS Center of Excellence, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Tiberio+GAM%22">Tiberio GAM</searchLink>; General Surgery, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Versari+A%22">Versari A</searchLink>; Nuclear Medicine Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Vigorito+R%22">Vigorito R</searchLink>; Division of Radiology, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Zatelli+MC%22">Zatelli MC</searchLink>; Department of Medical Sciences, Section of Endocrinology, Geriatrics and Internal Medicine, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Maio+M%22">Di Maio M</searchLink>; Department of Oncology, University of Turin, A.O. Ordine Mauriziano, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Perrone+F%22">Perrone F</searchLink>; Clinical Trial Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Cinieri+S%22">Cinieri S</searchLink>; Oncology and Breast Unit, Ospedale 'A. Perrino', Brindisi, Italy.<br /><searchLink fieldCode="AU" term="%22Panzuto+F%22">Panzuto F</searchLink>; Digestive Disease Unit, Department of Medical-Surgical Sciences and Translational Medicine, ENETS Center of Excellence, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy. Electronic address: francesco.panzuto@uniroma1.it.<br /><searchLink fieldCode="AU" term="%22Fazio+N%22">Fazio N</searchLink>; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, IRCCS, ENETS and EURACAN NEN Center of Excellence, Milan, Italy. Electronic address: nicola.fazio@ieo.it.
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  Data: <searchLink fieldCode="JN" term="%22101690685%22">ESMO open</searchLink> [ESMO Open] 2025 Nov; Vol. 10 (11), pp. 105878. <i>Date of Electronic Publication: </i>2025 Nov 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101690685 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-7029 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220597029%22">20597029 </searchLink><i>NLM ISO Abbreviation: </i>ESMO Open <i>Subsets: </i>MEDLINE
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