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Case Report: Complete response to the concurrent neoadjuvant radiation therapy and pembrolizumab in a locally recurrent, chemotherapy-refractory undifferentiated pleomorphic sarcoma of bone.

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Title: Case Report: Complete response to the concurrent neoadjuvant radiation therapy and pembrolizumab in a locally recurrent, chemotherapy-refractory undifferentiated pleomorphic sarcoma of bone.
Authors: Patel BA; The University of Texas at Austin College of Natural Sciences, Austin, TX, United States., Smith JT; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Wangsiricharoen S; Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, OR, United States., Wang WL; Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Lin PP; Department of Orthopedic Oncology, Division of Surgery The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Farooqi A; Division of Radiation Oncology The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Nassif Haddad EF; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Ummed K; Georgia Cancer Specialists, Atlanta, GA, United States., Mericli AF; The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Adelman DM; Department of Plastic Surgery The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Livingston JA; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States., Conley AP; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Source: Frontiers in oncology [Front Oncol] 2026 Feb 12; Vol. 16, pp. 1645629. Date of Electronic Publication: 2026 Feb 12 (Print Publication: 2026).
Publication Type: Case Reports; Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Case Report: Complete response to the concurrent neoadjuvant radiation therapy and pembrolizumab in a locally recurrent, chemotherapy-refractory undifferentiated pleomorphic sarcoma of bone.
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  Data: <searchLink fieldCode="AU" term="%22Patel+BA%22">Patel BA</searchLink>; The University of Texas at Austin College of Natural Sciences, Austin, TX, United States.<br /><searchLink fieldCode="AU" term="%22Smith+JT%22">Smith JT</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Wangsiricharoen+S%22">Wangsiricharoen S</searchLink>; Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, OR, United States.<br /><searchLink fieldCode="AU" term="%22Wang+WL%22">Wang WL</searchLink>; Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Lin+PP%22">Lin PP</searchLink>; Department of Orthopedic Oncology, Division of Surgery The University of Texas MD Anderson Cancer Center, Houston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Farooqi+A%22">Farooqi A</searchLink>; Division of Radiation Oncology The University of Texas MD Anderson Cancer Center, Houston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Nassif+Haddad+EF%22">Nassif Haddad EF</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Ummed+K%22">Ummed K</searchLink>; Georgia Cancer Specialists, Atlanta, GA, United States.<br /><searchLink fieldCode="AU" term="%22Mericli+AF%22">Mericli AF</searchLink>; The University of Texas MD Anderson Cancer Center, Houston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Adelman+DM%22">Adelman DM</searchLink>; Department of Plastic Surgery The University of Texas MD Anderson Cancer Center, Houston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Livingston+JA%22">Livingston JA</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.<br /><searchLink fieldCode="AU" term="%22Conley+AP%22">Conley AP</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
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  Data: <searchLink fieldCode="JN" term="%22101568867%22">Frontiers in oncology</searchLink> [Front Oncol] 2026 Feb 12; Vol. 16, pp. 1645629. <i>Date of Electronic Publication: </i>2026 Feb 12 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101568867 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2234-943X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222234943X%22">2234943X </searchLink><i>NLM ISO Abbreviation: </i>Front Oncol <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41768232
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