Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model.
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| Title: | Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model. |
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| Authors: | Chen JH; Department of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan.; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Chang CW; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen YY; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan., Yang CH; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Research Center for Neuroscience, Taipei Medical University, Taipei, Taiwan., Yang WB; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Research Center for Neuroscience, Taipei Medical University, Taipei, Taiwan., Hsieh YC; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Liang YW; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan., Li SJ; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan., Hu CJ; Department of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan.; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. |
| Source: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Mar; Vol. 22 (3), pp. e71290. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41841574 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chen+JH%22">Chen JH</searchLink>; Department of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan.; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CW%22">Chang CW</searchLink>; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YY%22">Chen YY</searchLink>; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+CH%22">Yang CH</searchLink>; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Research Center for Neuroscience, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+WB%22">Yang WB</searchLink>; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Research Center for Neuroscience, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+YC%22">Hsieh YC</searchLink>; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liang+YW%22">Liang YW</searchLink>; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+SJ%22">Li SJ</searchLink>; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hu+CJ%22">Hu CJ</searchLink>; Department of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan.; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Mar; Vol. 22 (3), pp. e71290. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41841574 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/alz.71290 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e71290 Titles: – TitleFull: Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen JH – PersonEntity: Name: NameFull: Chang CW – PersonEntity: Name: NameFull: Chen YY – PersonEntity: Name: NameFull: Yang CH – PersonEntity: Name: NameFull: Yang WB – PersonEntity: Name: NameFull: Hsieh YC – PersonEntity: Name: NameFull: Liang YW – PersonEntity: Name: NameFull: Li SJ – PersonEntity: Name: NameFull: Hu CJ IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2026 Mar Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1552-5279 Numbering: – Type: volume Value: 22 – Type: issue Value: 3 Titles: – TitleFull: Alzheimer's & dementia : the journal of the Alzheimer's Association Type: main |
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