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Graph Topology Reframes the Coherence of Cell-State Manifold Inference under Heterogeneous Single-Cell Observations.

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Title: Graph Topology Reframes the Coherence of Cell-State Manifold Inference under Heterogeneous Single-Cell Observations.
Authors: Tamura T; Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine and Graduate School of Medicine, Shinjuku, Japan.; Department of Diabetes, Endocrinology, and Metabolism, National Center for Global Health and Medicine, Japan Institute for Health Security, Shinjuku, Japan.; Laboratory of Cancer Cell Systems, National Cancer Center Research Institute, Chuo, Japan., Yamane Y; Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine and Graduate School of Medicine, Shinjuku, Japan., Okano Y; Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine and Graduate School of Medicine, Shinjuku, Japan.; Division of Applied Mathematical Science, RIKEN Center for Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS), RIKEN, Yokohama, Japan., Ishikawa T; Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine and Graduate School of Medicine, Shinjuku, Japan.; Division of Applied Mathematical Science, RIKEN Center for Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS), RIKEN, Yokohama, Japan.; Collective Intelligence Research Laboratory, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan., Sakurada K; Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine and Graduate School of Medicine, Shinjuku, Japan.; Predictive Medicine Special Project, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Source: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2026 Jun 03; Vol. 35 (1), pp. 0087. Date of Electronic Publication: 2026 Jun 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology Country of Publication: Netherlands NLM ID: 101585369 Publication Model: eCollection Cited Medium: Print ISSN: 2001-0370 (Print) Linking ISSN: 20010370 NLM ISO Abbreviation: Comput Struct Biotechnol J Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Graph Topology Reframes the Coherence of Cell-State Manifold Inference under Heterogeneous Single-Cell Observations.
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  Data: <searchLink fieldCode="AU" term="%22Tamura+T%22">Tamura T</searchLink>; Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine and Graduate School of Medicine, Shinjuku, Japan.; Department of Diabetes, Endocrinology, and Metabolism, National Center for Global Health and Medicine, Japan Institute for Health Security, Shinjuku, Japan.; Laboratory of Cancer Cell Systems, National Cancer Center Research Institute, Chuo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamane+Y%22">Yamane Y</searchLink>; Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine and Graduate School of Medicine, Shinjuku, Japan.<br /><searchLink fieldCode="AU" term="%22Okano+Y%22">Okano Y</searchLink>; Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine and Graduate School of Medicine, Shinjuku, Japan.; Division of Applied Mathematical Science, RIKEN Center for Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS), RIKEN, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ishikawa+T%22">Ishikawa T</searchLink>; Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine and Graduate School of Medicine, Shinjuku, Japan.; Division of Applied Mathematical Science, RIKEN Center for Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS), RIKEN, Yokohama, Japan.; Collective Intelligence Research Laboratory, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan.<br /><searchLink fieldCode="AU" term="%22Sakurada+K%22">Sakurada K</searchLink>; Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine and Graduate School of Medicine, Shinjuku, Japan.; Predictive Medicine Special Project, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101585369%22">Computational and structural biotechnology journal</searchLink> [Comput Struct Biotechnol J] 2026 Jun 03; Vol. 35 (1), pp. 0087. <i>Date of Electronic Publication: </i>2026 Jun 03 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%2E+on+behalf+of+Research+Network+of+Computational+and+Structural+Biotechnology%22">Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101585369 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2001-0370 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220010370%22">20010370 </searchLink><i>NLM ISO Abbreviation: </i>Comput Struct Biotechnol J <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.34133/csbj.0087
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        Text: English
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              Text: 2026 Jun 03
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