Gravitational unloading inhibits the regenerative potential of atrophied soleus muscle in mice.
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| Title: | Gravitational unloading inhibits the regenerative potential of atrophied soleus muscle in mice. |
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| Authors: | Matsuba, Y., Goto, K., Morioka, S., Naito, T., Akema, T., Hashimoto, N., Sugiura, T., Ohira, Y., Beppu, M., Yoshioka, T. |
| Source: | Acta Physiologica. Jul2009, Vol. 196 Issue 3, p329-339. 11p. 2 Diagrams, 5 Graphs. |
| Subjects: | Regenerative medicine, Regeneration (Biology), Muscle contraction, Muscle diseases, Compartment syndrome, Contracture (Pathology), Rat diseases |
| Abstract: | Aim: The present study was performed to investigate the influence of unloading on the regeneration of atrophied and injured skeletal muscle. Methods: Male mice (C57BL/6J), aged 8 weeks, were used. Cardiotoxin (CTX) was injected into soleus muscles bilaterally. Gravitational unloading on soleus muscle was performed by hind limb suspension for 2 weeks before and additionally 6 weeks after CTX injection in one group. Soleus muscles in the remaining groups were loaded keeping the mice in the cages and were dissected 14, 28 and 42 days after the injection. Results: Recovery of the wet weight and protein content of soleus in the CTX-injected group was inhibited by unloading. Increase in satellite cell number, induced by CTX injection and loading, was also inhibited by unloading. Disappearance of infiltration of mononucleated cells into the necrotic area was also delayed. This phenomenon suggests that regeneration, which is indicated by the appearance of fibres with central nuclei, was inhibited by unloading. Conclusion: Results suggested that loading plays an important role in the activation of the regenerating potential of injured skeletal muscle. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 41228795 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Gravitational unloading inhibits the regenerative potential of atrophied soleus muscle in mice. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Matsuba%2C+Y%2E%22">Matsuba, Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Goto%2C+K%2E%22">Goto, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Morioka%2C+S%2E%22">Morioka, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Naito%2C+T%2E%22">Naito, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Akema%2C+T%2E%22">Akema, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Hashimoto%2C+N%2E%22">Hashimoto, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Sugiura%2C+T%2E%22">Sugiura, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Ohira%2C+Y%2E%22">Ohira, Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Beppu%2C+M%2E%22">Beppu, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Yoshioka%2C+T%2E%22">Yoshioka, T.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Jul2009, Vol. 196 Issue 3, p329-339. 11p. 2 Diagrams, 5 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Regenerative+medicine%22">Regenerative medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Regeneration+%28Biology%29%22">Regeneration (Biology)</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+contraction%22">Muscle contraction</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+diseases%22">Muscle diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Compartment+syndrome%22">Compartment syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Contracture+%28Pathology%29%22">Contracture (Pathology)</searchLink><br /><searchLink fieldCode="DE" term="%22Rat+diseases%22">Rat diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aim: The present study was performed to investigate the influence of unloading on the regeneration of atrophied and injured skeletal muscle. Methods: Male mice (C57BL/6J), aged 8 weeks, were used. Cardiotoxin (CTX) was injected into soleus muscles bilaterally. Gravitational unloading on soleus muscle was performed by hind limb suspension for 2 weeks before and additionally 6 weeks after CTX injection in one group. Soleus muscles in the remaining groups were loaded keeping the mice in the cages and were dissected 14, 28 and 42 days after the injection. Results: Recovery of the wet weight and protein content of soleus in the CTX-injected group was inhibited by unloading. Increase in satellite cell number, induced by CTX injection and loading, was also inhibited by unloading. Disappearance of infiltration of mononucleated cells into the necrotic area was also delayed. This phenomenon suggests that regeneration, which is indicated by the appearance of fibres with central nuclei, was inhibited by unloading. Conclusion: Results suggested that loading plays an important role in the activation of the regenerating potential of injured skeletal muscle. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1748-1716.2008.01943.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 329 Subjects: – SubjectFull: Regenerative medicine Type: general – SubjectFull: Regeneration (Biology) Type: general – SubjectFull: Muscle contraction Type: general – SubjectFull: Muscle diseases Type: general – SubjectFull: Compartment syndrome Type: general – SubjectFull: Contracture (Pathology) Type: general – SubjectFull: Rat diseases Type: general Titles: – TitleFull: Gravitational unloading inhibits the regenerative potential of atrophied soleus muscle in mice. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Matsuba, Y. – PersonEntity: Name: NameFull: Goto, K. – PersonEntity: Name: NameFull: Morioka, S. – PersonEntity: Name: NameFull: Naito, T. – PersonEntity: Name: NameFull: Akema, T. – PersonEntity: Name: NameFull: Hashimoto, N. – PersonEntity: Name: NameFull: Sugiura, T. – PersonEntity: Name: NameFull: Ohira, Y. – PersonEntity: Name: NameFull: Beppu, M. – PersonEntity: Name: NameFull: Yoshioka, T. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 17481708 Numbering: – Type: volume Value: 196 – Type: issue Value: 3 Titles: – TitleFull: Acta Physiologica Type: main |
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